Digital Pathology Scoring of Immunohistochemical Staining Reliablity Identifies Prognostic Markers and Anatomical Associations in a Large Cohort of Oral Cancers
Moratin J, Mock A, Obradovic S, Metzger K, Flechtenmacher C, Zaoui K, Fröhling S, Jäger D, Krauss J, Hoffmann J, Freier K, Horn D, Hess J, Freudlsperger C.
Front Oncol. 2021 Jul 29;11:712944. doi: 10.3389/fonc.2021.712944. eCollection 2021.
EGFR and PI3K pathway activities might guide drug repurposing in HPV-negative head and neck cancers
Mock A, Plath M, Moratin J, Tapken MJ, Jäger D, Krauss J, Fröhling S, Hess J, Zaoui K.
Front Oncol. 2021 Jun 11;11:678966. doi: 10.3389/fonc.2021.678966. eCollection 2021.
Comprehensive Genomic and Transcriptomic Analysis for Guiding Therapeutic Decisions in Patients with Rare Cancers
Horak P*, Heining C*, Kreutzfeldt S*, Hutter B*, Mock A**, Hüllein J**, Fröhlich M**, Uhrig S**, Jahn A, Rump A, Gieldon L, Möhrmann L, Hanf D, Teleanu V, Heilig CE, Lipka DE, Allgäuer M, Ruhnke L, Laßmann A, Endris V, Neumann O, Penzel R, Beck K, Richter D, Winter U, Wolf S, Pfütze K, Geörg C, Meißburger B, Buchhalter I, Agustin M, Aulitzky WE, Hohenberger P, Kroiss M, Schirmacher P, Schlenk R, Keilholz U, Klauschen F, Folprecht G, Bauer S, Siveke JT, Brandts CH, Kindler T, Boerries M, Illert AL, von Bubnoff N, Jost PJ, Spiekermann K, Bitzer M, Schulze-Osthoff, von Kalle C, Klinik B, Brors B, STenzinger A, Schröck E, Hübschmann D, Weichert W, Glimm H, Fröhling S.
Cancer Discov. 2021 Jun 10:candisc.0126.2021. doi: 10.1158/2159-8290.CD-21-0126. Online ahead of print.
Perioperative changes in the plasma metabolome of patients receiving general anesthesia for pancreatic cancer surgery
Mock-Ohnesorge J, Mock A, Hackert T, Fröhling S, Schenz J, Poschet G, Jäger D, Büchler M, Uhle F, Weigand M.
Oncotarget. 2021 12:996-1010. doi: 10.18632/oncotarget.27956
Knowledge Bases and Software Support for Variant Interpretation in Precision Oncology
Borchert F*, Mock A*, Tomczak A*, Hügel J, Alkarkoukly S, Knurr A, Volckmar AL, Stenzinger A, Schirmacher P, Debus J, Jäger D, Longerich T, Fröhling S, Eils R, Bougatf N, Sax U, Schapranow MP.
Brief Bioinform. 2021 May 10:bbab134. doi: 10.1093/bib/bbab134. Online ahead of print.
Prognostic value of microRNA-221/2 and 17-92 families in primary glioblastoma patients treated with postoperative radiotherapy
Schnabel E, Knoll M, Schwager C, Warta R, Mock A, Campos B, König L, Jungk C, Wick W, Unterberg A, Debus J, Herold-Mende C, Abdollahi A.
Int J Mol Sci. 2021 Mar 15;22(6):2960. doi: 10.3390/ijms22062960.
Completion rate and impact on physician-patient relationship of video consultations in medical oncology: a randomised controlled open-label trial
Walle T, Erdal E, Muehlsteffen L, Singh HM, Gnutymann E, Gruen B, Hofmann H, Ivanova A, Koehler B, Korell F, Mavratzas A, Mock A, Pixberg C, Schult D, Starke H, Steinebrunner N, Woydack L, Schneeweiss A, Dietrich M, Jaeger D, Krisam J, Kather JN, Winkler EC.
ESMO Open. 2020 Nov;5(6):e000912. doi: 10.1136/esmoopen-2020-000912.
Identification of BCL-XL as highly active survival factor and promising therapeutic target in colorectal cancer
Scheer AL, Mock A, Gdynia G, Schmitt N, Heilig CE, Korell F, Rhadakrishnan P, Hoffmeister P, Metzeler KH, Schulze-Osthoff K, Iller AL, Boerries M, Trojan J, Waidmann O, Falkenhorst J, Siveke J, Jost PJ, Bityer M, Malek NP, Vecchione L, Jelas I, Brors B, Glimm H, Stenzinger A, Grekova S, Gehrig T, Schulze-Bergkamen H, Jäger D, Schirmacher P, Heikenwalder M, Goeppert B, Schneider M, Fröhling S, Köhler BC.
Cell Death Dis. 2020 Oct 17;11(10):875. doi: 10.1038/s41419-020-03092-7.
Patient-derived organoids and orthotopic xenografts of primary and recurrent gliomas represent relevant patient avatars for precision oncology
Golebiewska A, Hau AC, Oudin A, Stieber D, Yabo YA, Baus V, Barthelemy V, Klein E, Bougnaud S, Keunen O, Wantz M, Michelucci A, Nierinckx V, Muller A, Koama T, Nazarov PV, Azuaje F, De Falco A, Flies B, Richart L, Poovathingal S, Arns T, Grzyb K, Mock A, Herold-Mende C, Steino A, Brown D, May P, Miletic H, Malta TM, Noushmehr H, Kwon Young-Jun, Jahn W, Klink B, Tanner G, Stead LF, Mittelbronn M, Skupin A, Hertel F, Bjerkvig R, Niclou SP.
Acta Neuropathologica. 2020 Dec;140(6):919-949. doi: 10.1007/s00401-020-02226-7. Epub 2020 Oct 3.
Germline SDHB-inactivating mutation in non-GIST gastric spindle cell sarcoma
Heilig CE, Horak P, Lipka DB, Mock A, Uhrig S, Kreutzfeldt S, Richter S, Gieldon L, Fröhlich M, Hutter B, Hübschmann D, Teleanu V, Schmier JW, Philipzen J, Beuthien-Baumann B, Schröck E, von Deimling A, Bauer S, Heining C, Mechtersheimer G, Stenzinger A, Brors B, Wardelmann E, Glimm H, Hartmann W, Fröhling S.
Genes Chromosomes Cancer. 2020 Jun 5. doi: 10.1002/gcc.22876. Online ahead of print.
The landscape of chromothripsis across adult cancer types
Voronina N, Wong JKL, Hübschmann D, Hlevnjak M, Uhrig S, Heilig C, Horak P, Kreutzfeldt S, Mock A, Stenzinger A, Hutter B, Fröhlich M, Brors B, Jahn A, Klink B, Gieldon L, Sieverling L, Feuerbach L, Chudasama P, Beck K, Kroiss M, Heining C, Möhrmann L, Fischer A, Schröck E, Glimm H, Zapatka M, Lichter P, Fröhling S, Ernst A.
Nat Commun. 2020 May 8;11(1):2320. doi: 10.1038/s41467-020-16134-7.
Integrative kinomics reveals kinase-driven subtypes of gastric adenocarcinomas with sunitinib as a potential common inhibitor
Tapken M, Haag M, Jäger D, Fröhling S, Mock A.
bioRxiv 2020 doi: 10.1101/2020.02.12.944371
Surfactant expression defines an inflamed stratum of lung adenocarcinoma brain metastases
Pocha K*, Mock A*, Rapp C, Dettling S, Warta R, Geisenberger C, Jungk C, Martins L, Grabe N, Reuss D, Debus J, von Deimling A, Abdollahi A, Unterberg A, Herold-Mende C.
Clin Cancer Res. 2020 Jan 17. pii: clincanres.2184.2019. doi: 10.1158/1078-0432.CCR-19-2184. [Epub ahead of print]
Community-driven development of a modified progression-free survival ratio for precision oncology
Mock A, Heilig C, Kreutzfeldt S, Hübschmann D, Heining C, Schröck E, Brors B, Stenzinger A, Jäger D, Schlenk R, Glimm H, Fröhling S, Horak P. DKTK MASTER Network.
ESMO Open. 2019 Nov 13. doi: 10.1136/esmoopen-2019-000583
Serum very long-chain fatty acid-containing lipids predict response to immune checkpoint inhibitors in urological cancers
Mock A*, Zschäbitz S*, Kirsten R, Scheffer M, Wolf B, Herold-Mende C, Kreuter R, Busch E, Jenzer M, Jäger D, Grüllich C.
Cancer Immunol Immunother. 2019 Nov 7. doi: 10.1007/s00262-019-02428-3. [Epub ahead of print]
Treatment outcome of 227 patients with sinonasal adenoid cystic carcinoma (ACC) after intensity modulated radiotherapy and active raster-scanning carbon ion-boost: a 10-year single-center experience
Akbaba S, Ahmed D, Mock A, Held T, Bahadir S, Lang K, Sayed M, Hoerner-Rieber J, Forster T, Federspil P, Herfarth K, Plinkert P, Debus J, Adeberg S.
Cancers. 2019, 11(11), 1705; doi: 10.3390/cancers11111705
The impact of age on the outcome of patients treated with radiotherapy for mucoepidermoid carcinoma (MEC) of the salivary glands in the head and neck: A 15-year single-center experience
Akbaba S, Heusel A, Mock A, Held T, Lang K, Hoerner-Rieber J, Forster T, Katayama S, Kargus S, Rieken S, Plinkert P, Herfarth K, Debus J, Adeberg S.
Oral Oncology. 2019 Oct;97:115-123. doi: 10.1016/j.oraloncology.2019.08.018. Epub 2019 Sep 5.
Treatment outcome of a combined dose-escalated treatment regime with helical TomoTherapy® and active raster-scanning carbon ion boost for adenocarcinomas of the head and neck
Akbaba S, Mock A, Hoerner-Rieber J, Held T, Katayama S, Forster T, Freudlsperger C, Rieken S, Herfarth K, Plinkert P, Debus J, Adeberg S.
Front Oncol. 2019 Aug 13;9:755. doi: 10.3389/fonc.2019.00755. eCollection 2019.
Cytotoxic T-cells and their activation status are independent prognostic markers in meningiomas.
Rapp C, Dettling S, Liu F, Ull AT, Warta R, Jungk C, Roesch S, Mock A, Sahm F, Schmidt M, Jungwirth G, Zweckberger K, Lamszus K, Gousias K, Kessler AF, Grabe N, Löhr M, Ketter R, Urbschat S, Senft C, Westphal M, Abdollahi A, Debus J, von Deimling A, Unterberg A, Simon M, Herold-Mende CC.
Clin Cancer Res. 2019 Sep 1;25(17):5260-5270. doi: 10.1158/1078-0432.CCR-19-0389. Epub 2019 Jun 21.
Impact of post-surgical freezing delay on brain tumor metabolomics
Mock A, Rapp C, Warta R, Abdollahi A, Jäger D, Sakowitz O, Brors B, von Deimling A, Jungk C, Unterberg A, Herold-Mende C.
Metabolomics. 2019 May 13;15(5):78. doi: 10.1007/s11306-019-1541-2.
Location-dependent patient outcome and recurrence patterns in IDH1-wildtype glioblastoma
Jungk C, Warta R, Mock A, Friauf S, Hug B, Capper D, Abdollahi A, Debus J, Bendszus M, von Deimling A, Unterberg A, Herold-Mende C.
Cancers. 2019, 11(1), 122; doi: 10.3390/cancers11010122.
MetaboDiff: an R package for differential metabolomic analysis
Mock A, Warta R, Dettling S, Brors B, Jäger D, Herold-Mende C.
Bioinformatics. 2018 Oct 1;34(19):3417-3418. doi: 10.1093/bioinformatics/bty344.
Drug-perturbation-based stratification of blood cancer.
Dietrich S, Oleś M, Lu J, Sellner L, Anders S, Velten B, Wu B, Hüllein J, da Silva Liberio M, Walther T, Wagner L, Rabe S, Ghidelli-Disse S, Bantscheff M, Oleś AK, Słabicki M, Mock A, Oakes CC, Wang S, Oppermann S, Lukas M, Kim V, Sill M, Benner A, Jauch A, Sutton LA, Young E, Rosenquist R, Liu X, Jethwa A, Lee KS, Lewis J, Putzker K, Lutz C, Rossi D, Mokhir A, Oellerich T, Zirlik K, Herling M, Nguyen-Khac F, Plass C, Andersson E, Mustjoki S, von Kalle C, Ho AD, Hensel M, Dürig J, Ringshausen I, Zapatka M, Huber W, Zenz T.
J Clin Invest. 2018 Jan 2;128(1):427-445. doi: 10.1172/JCI93801. Epub 2017 Dec 11.
The 2016 WHO classification of central nervous system tumors: what neurologists need to know
DeWitt JC*, Mock A*, Louis DN.
Curr Opin Neurol. 2017 Dec;30(6):643-649. doi: 10.1097/WCO.0000000000000490. Review.
CVE: an R package for interactive variant prioritisation in precision oncology
Mock A, Murphy S, Morris J, Marass F, Rosenfeld N, Massie C.
BMC Med Genomics. 2017 May 25;10(1):37. doi: 10.1186/s12920-017-0261-6.
Spatial transcriptome analysis reveals Notch pathway-associated prognostic markers in IDH1 wild-type glioblastoma involving the subventricular zone
Jungk C, Mock A, Exner J, Geisenberger C, Warta R, Capper D, Abdollahi A, Friauf S, Lahrmann B, Grabe N, Beckhove P, von Deimling A, Unterberg A, Herold-Mende C.
BMC Med. 2016 Oct 26;14(1):170.
Prognostic value of the extent of resection in supratentorial WHO grade II astrocytomas stratified for IDH1 mutation status: a single-center volumetric analysis.
Jungk C, Scherer M, Mock A, Capper D, Radbruch A, von Deimling A, Bendszus M, Herold-Mende C, Unterberg A.
J Neurooncol. 2016 Sep;129(2):319-28. doi: 10.1007/s11060-016-2177-y.
Combined Treatment of ATRA with Epigenetic Drugs Increases Aggressiveness of Glioma Xenografts.
Schmoch T, Gal Z, Mock A, Mossemann J, Lahrmann B, Grabe N, Schmezer P, Lasitschka F, Beckhove P, Unterberg A, Herold-Mende C.
Anticancer Res. 2016 Apr;36(4):1489-96.
LOC283731 promoter hypermethylation prognosticates survival after radiochemotherapy in IDH1 wild-type glioblastoma patients.
Mock A*, Geisenberger C*, Orlik C, Warta R, Schwager C, Jungk C, Dutruel C, Geiselhart L, Weichenhan D, Zucknick M, Nied AK, Friauf S, Exner J, Capper D, Hartmann C, Lahrmann B, Grabe N, Debus J, von Deimling A, Popanda O, Plass C, Unterberg A, Abdollahi A, Schmezer P, Herold-Mende C.
Int J Cancer. 2016 Jul 15;139(2):424-32. doi: 10.1002/ijc.30069. Epub 2016 Mar 18.
Transcriptomic analysis of aggressive meningiomas identifies PTTG1 and LEPR as prognostic biomarkers independent of WHO grade.
Schmidt M*, Mock A*, Jungk C, Sahm F, Ull AT, Warta R, Lamszus K, Gousias K, Ketter R, Roesch S, Rapp C, Schefzyk S, Urbschat S, Lahrmann B, Kessler AF, Löhr M, Senft C, Grabe N, Reuss D, Beckhove P, Westphal M, von Deimling A, Unterberg A, Simon M, Herold-Mende C.
Oncotarget. 2016 Mar 22;7(12):14551-68. doi: 10.18632/oncotarget.7396.
Molecular profiling of long-term survivors identifies a subgroup of glioblastoma characterized by chromosome 19/20 co-gain.
Geisenberger C*, Mock A*, Warta R, Rapp C, Schwager C, Korshunov A, Nied AK, Capper D, Brors B, Jungk C, Jones D, Collins VP, Ichimura K, Bäcklund LM, Schnabel E, Mittelbron M, Lahrmann B, Zheng S, Verhaak RG, Grabe N, Pfister SM, Hartmann C, von Deimling A, Debus J, Unterberg A, Abdollahi A, Herold-Mende C.
Acta Neuropathol. 2015 Sep;130(3):419-34. doi: 10.1007/s00401-015-1427-y. Epub 2015 May 1.
Non-invasive glioblastoma immunoprofiling by printed peptide arrays.
Mock A, Herold-Mende C.
Oncoimmunology. 2015 Aug 12;5(2):e1069941. eCollection 2016 Feb.
Endothelial Cells Derived from Non-malignant Tissues Are of Limited Value as Models for Brain Tumor Vasculature.
Lohr J*, Mock A*, Beckhove P, Herold-Mende C.
Anticancer Res. 2015 May;35(5):2681-90.
Printed peptide arrays identify prognostic TNC serumantibodies in glioblastoma patients.
Mock A, Warta R, Geisenberger C, Bischoff R, Schulte A, Lamszus K, Stadler V, Felgenhauer T, Schichor C, Schwartz C, Matschke J, Jungk C, Ahmadi R, Sahm F, Capper D, Glass R, Tonn JC, Westphal M, von Deimling A, Unterberg A, Bermejo JL, Herold-Mende C.
Oncotarget. 2015 May 30;6(15):13579-90.
Microenvironment and brain tumor stem cell maintenance: impact of the niche.
Herold-Mende C, Mock A.
Anticancer Agents Med Chem. 2014;14(8):1065-74. Review.
Reduced promoter methylation and increased expression of CSPG4 negatively influences survival of HNSCC patients.
Warta R, Herold-Mende C, Chaisaingmongkol J, Popanda O, Mock A, Mogler C, Osswald F, Herpel E, Küstner S, Eckstein V, Plass C, Plinkert P, Schmezer P, Dyckhoff G.
Int J Cancer. 2014 Dec 1;135(11):2727-34. doi: 10.1002/ijc.28906. Epub 2014 Apr 26.
Lessons we learned from high-throughput and top-down systems biology analyses about glioma stem cells.
Mock A, Chiblak S, Herold-Mende C.
Curr Pharm Des. 2014;20(1):66-72. Review.